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Proteintech
APC2 Polyclonal Antibody
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Product Details
13559-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APC2 Fusion Protein Ag4427 (524-822 aa encoded by BC032503)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ADRLLHQFS FSPEREIRNV ELLKLRFGEA PMHFCEVMLK DMADSRRINA NIREEDEKRP AEEQPPFGVY AVILSSEFWP PFKDEKLEVP EDIRAALEAY CKKYEQLKAM RTLSWKHTLG LVTMDVELAD RTLSVAVTPV QAVILLYFQD QASWTLEELS KAVKMPVALL RRRMSVWLQQ GVLREEPPGT FSVIEEERPQ DRDNMVLIDS DDESDSGMAS QADQKEEELL LFWTYIQAML TNLESLSLDR IYNMLRMFVV TGPALAEIDL QELQGYLQKK VRDQQLVYSA GVYRLPKNCS (524-822 aa encoded by BC032503)
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adenomatosis polyposis coli 2; adenomatous polyposis coli like; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like
Gene Aliases: AI852447; APC2; APCL; R75424
UniProt ID: (Human) O95996
Entrez Gene ID: (Human) 10297, (Rat) 299611, (Mouse) 23805
biological_process
Wnt signaling pathway
negative regulation of catenin import into nucleus
negative regulation of canonical Wnt signaling pathway
cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
cell migration
regulation of cell differentiation
positive regulation of protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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