Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARPP-19; cAMP regulated phosphoprotein 19kDa; cAMP-regulated phosphoprotein 19; cAMP-regulated phosphoprotein 19kDa; cAMP-regulated phosphoprotein ARPP-19; cAMP-regulated phosphoprotein, 19kDa; cyclic AMP phosphoprotein, 19 kD; cyclic AMP phosphoprotein, 19 kDa; cyclic AMP phosphoprotein, 19kD
Gene Aliases: 19kDa; 2700024H10Rik; ARPP-16; ARPP-19; Arpp12; ARPP16; ARPP19; AW559096; ENSAL