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Invitrogen
AVPR2 Polyclonal Antibody
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FIGURE: 1 / 2
AVPR2 Antibody (PA5-75409) in WB
Western blot analysis of AVPR2 in Lane 1: 786-O whole cell lysate (40 µg), Lane 2: HEK293T whole cell lysate (40 µg), Lane 3: the kidney tissue lysate of mouse (40 µg), Lane 4: the kidney tissue lysate of rat (40 µg), Lane 5: PC12 whole cell lysate (40 µg). Samples were incubated with AVPR2 polyclonal antibody (Product # PA5-75409) at a dilution of 1:500.
Product Details
PA5-75409
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 80-130 of Human AVPR2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Avpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; alternatively spliced; truncated 3' end; Antidiuretic hormone receptor; Avp2r; AVPR V2; G protein-coupled receptor; MGC126533; MGC138386; nephrogenic diabetes insipidus; Renal-type arginine vasopressin receptor; V2-renal V2R; V2R; Vasopressin receptor V2; Vasopressin V2 receptor
Gene Aliases: ADHR; AVPR2; DI1; DIR; DIR3; ND1; NDI; NDI1; V2R; VPV2R
UniProt ID: (Human) P30518, (Mouse) O88721, (Rat) Q00788
Entrez Gene ID: (Human) 554, (Mouse) 12000, (Rat) 25108
regulation of systemic arterial blood pressure by vasopressin
positive regulation of systemic arterial blood pressure
renal water retention
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
hemostasis
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
telencephalon development
cellular response to hormone stimulus
response to cytokine
negative regulation of urine volume
positive regulation of blood pressure
positive regulation of vasoconstriction
renal water absorption
positive regulation of intracellular signal transduction
I-kappaB kinase/NF-kappaB signaling
interferon-gamma production
negative regulation of renal sodium excretion
response to peptide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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