PA5-29776 targets AXIN1 in WB applications and shows reactivity with Human samples.
The PA5-29776 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 268 of Human AXIN1.
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This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
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Protein Aliases: AXIN; Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; homolog of; mouse; PPP1R49; Protein Fused; protein phosphatase 1; protein phosphatase 1, regulatory subunit 49; rAxin; regulatory subunit 49
Gene Aliases: AI316800; AXIN; AXIN1; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49