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Invitrogen
BAG5 Polyclonal Antibody
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FIGURE: 1 / 3
BAG5 Antibody (PA5-96429) in IHC (P)
Immunohistochemistry analysis of BAG5 in paraffin-embedded human stomach. Samples were incubated with BAG5 Polyclonal antibody (Product # PA5-96429) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96429
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 198-447 of human BAG5 (NP_0048641)
Conjugate
Form
Liquid
Concentration
0.58 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GVLIALLMGV NNNETCRHLS CVLSGLIADL DALDVCGRTE IRNYRREVVE DINKLLKYLD LEEEADTTKA FDLRQNHSIL KIEKVLKRMR EIKNELLQAQ NPSELYLSSK TELQGLIGQL DEVSLEKNPC IREARRRAVI EVQTLITYID LKEALEKRKL FACEEHPSHK AVWNVLGNLS EIQGEVLSFD GNRTDKNYIR LEELLTKQLL ALDAVDPQGE EKCKAARKQA VRLAQNILSY LDLKSDEWEY; Positive Samples: SH-SY5Y, MCF7, Mouse lung, Mouse testis, Rat brain, Rat lung
Target Information
It has been hypothesizes that the BAG-5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70's anti-apoptotic function. It is believed that BAG-5 will play an important role in the mechanisms of neuronal death. BAG-5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/ modulation of other BAG containing proteins via BAG-BAG heterodimerization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAG family molecular chaperone regulator 5; BAG-5; BAG-family molecular chaperone regulator-5; BAG-family molecular chaperone regulator-5 (BAG-5); Bcl-2-associated athanogene 5; BCL2-associated athanogene 5
Gene Aliases: 1600025G07Rik; 4930405J06Rik; BAG-5; BAG5; KIAA0873
UniProt ID: (Human) Q9UL15, (Rat) Q5QJC9, (Mouse) Q8CI32
Entrez Gene ID: (Human) 9529, (Rat) 366734, (Mouse) 70369
negative regulation of protein ubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of ubiquitin-protein transferase activity
negative regulation of protein refolding
neuron death
regulation of inclusion body assembly
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
protein folding
Golgi organization
negative regulation of neuron projection development
regulation of ubiquitin-protein transferase activity
regulation of cellular response to heat
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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