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Proteintech
BCOR Polyclonal Antibody
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Product Details
12107-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCOR Fusion Protein Ag2752 (2-361 aa encoded by BC009675)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RFRKRPEPS SDYDLSPAKQ EPKPFDRLQQ LLPASQSTQL PCSSSPQETT QSRPMPPEAR RLIVNKNAGE TLLQRAARLG YEEVVLYCLE NKICDVNHRD NAGYCALHEA CARGWLNIVR HLLEYGADVN CSAQDGTRPL HDAVENDHLE IVRLLLSYGA DPTLATYSGR TIMKMTHSEL MEKFLTDYLN DLQGRNDDDA SGTWDFYGSS VCEPDDESGY DVLANPPGPE DQDDDDDAYS DVFEFEFSET PLLPCYNIQV SVAQGPRNWL LLSDVLKKLK MSSRIFRCNF PNVEIVTIAE AEFYRQVSAS LLFSCSKDLE AFNPESKELL DLVEFTNEIQ TLLGSSVEWL HPSDLASDNY W (2-361 aa encoded by BC009675)
Target Information
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BCL-6 corepressor; BCL-6 interacting corepressor; Bcl6 interacting corepressor; BCoR
Gene Aliases: 5830466J11Rik; 8430401K06Rik; ANOP2; BCOR; BcorR; D930024N20Rik; KIAA1575; MAA2; MCOPS2; mKIAA1575; RGD1562735
UniProt ID: (Human) Q6W2J9, (Mouse) Q8CGN4
Entrez Gene ID: (Human) 54880, (Rat) 317346, (Mouse) 71458
negative regulation of transcription from RNA polymerase II promoter
negative regulation of histone H3-K36 methylation
heart development
biological_process
negative regulation of bone mineralization
histone H2A monoubiquitination
odontogenesis
negative regulation of transcription, DNA-templated
negative regulation of histone H3-K4 methylation
palate development
specification of axis polarity
negative regulation of tooth mineralization
negative regulation of nucleic acid-templated transcription
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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