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Proteintech
BRD7 Polyclonal Antibody
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Product Details
51009-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BRD7 Fusion Protein Ag3911 (1-350 aa encoded by BC050728)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGKKHKKHK SDKHLYEEYV EKPLKLVLKV GGNEVTELST GSSGHDSSLF EDKNDHDKHK DRKRKKRKKG EKQIPGEEKG RKRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP VTDFIAPGYS MIIKHPMDFS TMKEKIKNND YQSIEELKDN FKLMCTNAMI YNKPETIYYK AAKKLLHSGM KILSQERIQS LKQSIDFMAD LQKTRKQKDG TDTSQSGEDG GCWQREREDS GDAEAHAFKS PSKENKKKDK DMLEDKFKSN NLEREQEQLD RIVKESGGKL TRRLVNSQCE FERRKPDGTT T (1-350 aa encoded by BC050728)
Target Information
BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 75 kDa bromodomain protein; bromodomain protein 75 kDa; bromodomain-containing 7; Bromodomain-containing protein 7; Protein CELTIX-1; protein tyrosine phosphatase, non-receptor type 13 interacting protein
Gene Aliases: BP75; BRD7; CELTIX1; NAG4; Ptpn13ip
UniProt ID: (Human) Q9NPI1, (Mouse) O88665
Entrez Gene ID: (Human) 29117, (Mouse) 26992, (Rat) 361374
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell cycle
negative regulation of cell proliferation
Wnt signaling pathway
positive regulation of histone acetylation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of signal transduction by p53 class mediator
negative regulation of G1/S transition of mitotic cell cycle
regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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