BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
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Protein Aliases: 75 kDa bromodomain protein; bromodomain protein 75 kDa; bromodomain-containing 7; Bromodomain-containing protein 7; Protein CELTIX-1; protein tyrosine phosphatase, non-receptor type 13 interacting protein
Gene Aliases: BP75; BRD7; CELTIX1; NAG4; Ptpn13ip
Molecular Function: chromatin/chromatin-binding, or -regulatory protein