Product References
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
11-9981-82 was used in Flow Cytometry to investigate TβRII and extracellular vesicle delivery in breast cancer to derive targets for immunotherapy.
Mon Aug 01 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
11-9981-82 was used in Flow Cytometry to investigate TβRII and extracellular vesicle delivery in breast cancer to derive targets for immunotherapy.
Mon Aug 01 00:00:00 EDT 2022
Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion.
iScience
Ma K,Sun L,Shen M,Zhang X,Xiao Z,Wang J,Liu X,Jiang K,Xiao-Feng Qin F,Guo F,Zhang B,Zhang L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 11-9981-82) in Flow Cytometry
Fri May 20 00:00:00 EDT 2022
Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes.
Nature communications
Tan TCJ,Kelly V,Zou X,Wright D,Ly T,Zamoyska R
11-9981-82 was used in Flow cytometry/Cell sorting to show that the function of the elongation factor, eIF5a, is regulated dynamically in naive CD8+ T cells upon activation by post-translational modification, whereupon it facilitates translation of specific subsets of proteins.
Sat Dec 17 00:00:00 EST 2022
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection.
Immunity
Ozga AJ,Chow MT,Lopes ME,Servis RL,Di Pilato M,Dehio P,Lian J,Mempel TR,Luster AD
11-9981-82 was used in Flow cytometry/Cell sorting to find that the chemokine receptor CXCR3 is highly expressed on viral-specific stem-like CD8+ T cells and that one of its ligands, CXCL10, regulates the persistence and heterogeneity of responding CD8+ T cells in spleens of mice chronically infected with lymphocytic choriomeningitis virus.
Tue Jan 11 00:00:00 EST 2022
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway.
Cell death discovery
Pu J,Xu Z,Nian J,Fang Q,Yang M,Huang Y,Li W,Ge B,Wang J,Wei H
Published figure using CD279 (PD-1) monoclonal antibody (Product # 11-9981-82) in Flow Cytometry
Fri Jul 16 00:00:00 EDT 2021
Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression.
Journal for immunotherapy of cancer
Pierini S,Mishra A,Perales-Linares R,Uribe-Herranz M,Beghi S,Giglio A,Pustylnikov S,Costabile F,Rafail S,Amici A,Facciponte JG,Koumenis C,Facciabene A
Published figure using CD279 (PD-1) monoclonal antibody (Product # 11-9981-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
Published figure using CD279 (PD-1) monoclonal antibody (Product # 11-9981-82) in Flow Cytometry
Thu Aug 20 00:00:00 EDT 2020
Creatine uptake regulates CD8 T cell antitumor immunity.
The Journal of experimental medicine
Di Biase S,Ma X,Wang X,Yu J,Wang YC,Smith DJ,Zhou Y,Li Z,Kim YJ,Clarke N,To A,Yang L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 11-9981-82) in Flow Cytometry
Mon Dec 02 00:00:00 EST 2019
Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Jiang H,Shin DH,Nguyen TT,Fueyo J,Fan X,Henry V,Carrillo CC,Yi Y,Alonso MM,Collier TL,Yuan Y,Lang FF,Gomez-Manzano C
11-9981 was used in Flow cytometry/Cell sorting to show that localized intratumoral injection of Delta-24-RGDOX induces an in situ antovaccination of the treated melanoma, the effect of which changes the immune landscape of the treated mice, resulting in systemic immunity against disseminated s.c. and i.c. tumors.
Fri Nov 15 00:00:00 EST 2019
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Cell reports
DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ
11-9981 was used in Flow cytometry/Cell sorting to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.
Tue Apr 09 00:00:00 EDT 2019
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
11-9981 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J
11-9981 was used in Flow cytometry/Cell sorting to evaluate how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer.
Thu Dec 01 00:00:00 EST 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
Published figure using CD279 (PD-1) monoclonal antibody (Product # 11-9981-82) in Flow Cytometry
Mon Aug 08 00:00:00 EDT 2016
Negative CD4 + TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Liu Y,Ji H,Zhang Y,Shen XD,Gao F,Nguyen TT,Shang X,Lee N,Busuttil RW,Kupiec-Weglinski JW
11-9981 was used in Flow cytometry/Cell sorting to explore TIM-3-Gal-9 function in a clinically relevant murine model of hepatic cold storage and orthotopic liver transplantation.
Wed Apr 01 00:00:00 EDT 2015
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950)
Ishiwata K,Watanabe N,Guo M,Tomihara K,Brumlik MJ,Yagita H,Pardoll D,Chen L,Shin T
11-9981 was used in Flow cytometry/Cell sorting to demonstrate that the inhibition of Th2 responses by B7-DC occurs independently of programmed death 1 but conceivably acts through an as yet unknown alternative receptor that enhances Th1 responses.
Mon Feb 15 00:00:00 EST 2010