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Invitrogen
CD31 Monoclonal Antibody (MBC78.2), PE
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FIGURE: 1 / 1
CD31 Antibody (MHCD3104) in Flow
Molecular medicine reports 2020 -
Figure 1. Expression levels of miR-195-5p and EZH2, and cell proliferation and apoptosis in healthy controls and GDM HUVECs. (A) Endothelial phenotype of healthy controls and GDM HUVECs was detected by flow cytometry using the CD31 marker. mRNA expression levels of (B) miR-195-5p and (C) EZH2 were determined by reverse transcription-quantitative polymerase chain reaction analysis. (D) Protein expression of ... View More
Product Details
MHCD3104
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MBC78.2
Immunogen
Human CD31
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
PBS with 4mg/mL BSA, 10% sucrose
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Analyte Specific Reagent
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
Bioinformatics
Protein Aliases: adhesion molecule; CD31; CD31 antigen; EndoCAM; GPIIA'; PECA1; PECAM-1; PECAM-1 precursor; Platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; unnamed protein product
Gene Aliases: CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; PECAM-1; PECAM1
UniProt ID: (Human) P16284
Entrez Gene ID: (Human) 5175
angiogenesis
blood vessel development
endothelial cell development
endothelial cell morphogenesis
phagocytosis
immune response
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
leukocyte cell-cell adhesion
signal transduction
cell surface receptor signaling pathway
Rho protein signal transduction
cell recognition
cell migration
regulation of cell migration
positive regulation of cell migration
maintenance of blood-brain barrier
monocyte extravasation
wound healing
vasodilation
positive regulation of MAPK cascade
endothelial cell migration
diapedesis
detection of mechanical stimulus
positive regulation of protein kinase B signaling
establishment of endothelial barrier
bicellular tight junction assembly
cellular response to mechanical stimulus
glomerular endothelium development
neutrophil extravasation
endothelial cell-matrix adhesion
cell-cell adhesion
cell-cell adhesion via plasma-membrane adhesion molecules
positive regulation of protein localization to cell-cell junction
positive regulation of intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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