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CD39/ENTPD1 Monoclonal Antibody (2D2H6), CoraLite® Plus 488
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FIGURE: 1 / 1
CD39/ENTPD1 Antibody (CL488-60323) in Flow
1X10^6 Jurkat cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human CD39/ENTPD1 (CL488-60323, Clone:2D2H6) (red), or 0.4 µg Mouse IgG2a Isotype Control (CL488-66360-2, Clone: K11A1B2A2) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-60323
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2D2H6
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MESEELADRV LDVVERSLSN YPFDFQGARI ITGQEEGAYG WITINYLLGK FSQKTRWFSI VPYETNNQET FGALDLGGAS TQVTFVPQNQ TIESPDNALQ FRLYGKDYNV YTHSFLCYGK DQALWQKLAK DIQVASNEIL RDPCFHPGYK KVVNVSDLYK TPCTKRFEMT LPFQQFEIQG IGNYQQCHQS ILELFNTSYC PYSQCAFNGI FLPPLQGDFG AFSAFYFVMK FLNLTSEKVS QEKVTEMMKK FCAQPWEEIK TSYAGVKEKY LSEYCFSGTY ILSLLLQGYH FTADSWEHIH FIGKIQGSDA GWTLGYMLNL TNMIPAEQPL STPLSHSTYV
Target Information
CD39 is an integral membrane protein characterized by two transmembrane domains and forms a homotetramer structure. It is recognized as the most prominent ectoenzyme within the immune system, primarily functioning to remove toxic extracellular ATP by converting it into ADP or AMP. CD39 works in conjunction with CD73 to hydrolyze ATP and is well characterized on Langerhans cells. Originally identified on activated lymphocytes, CD39 is expressed on a variety of immune cells, including peripheral blood B cells, monocytes, and T cell clones. It is also found on a subset of T cells, B cells, and dendritic cells, with weaker expression observed on monocytes and granulocytes. The CD39 cell surface antigen is a 70-100kD molecule, and its expression is induced on T cells and increases on B cells as a late activation antigen. CD39 possesses intrinsic ecto-ATPase activity, playing a crucial role in modulating extracellular nucleotide levels and contributing to immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP diphosphohydrolase; ATP-DPH; CD39; CD39 antigen; DKFZp686D194; DKFZp686I093; Ecto-apyrase; Ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; Ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; FLJ40921; FLJ40959; guanosine diphosphatase homolog; Lymphoid cell activation antigen; NTPDase1; Nucleoside triphosphate diphosphohydrolase 1; unnamed protein product
Gene Aliases: ATP-DPH; ATPDase; CD39; ENTPD1; NTPDase-1; SPG64
UniProt ID: (Human) P49961
Entrez Gene ID: (Human) 953
nucleotide binding
GTPase activity
obsolete apyrase activity
guanosine-diphosphatase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
nucleoside-diphosphatase activity
nucleoside-triphosphatase activity
cytidine diphosphatase activity
adenosine-diphosphatase activity
CTPase activity
uridine-diphosphatase activity
ITPase activity
IDP phosphatase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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