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SP1 Monoclonal Antibody (4G3H3), CoraLite® Plus 488

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SP1 Monoclonal Antibody (4G3H3), CoraLite® Plus 488

Product Details

CL488-66508

Applications
Tested Dilution
Publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4G3H3

Immunogen

SP1 fusion protein Ag16720
View immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: NLQLQAVPNS GPIIIRTPTV GPNGQVSWQT LQLQNLQVQN PQAQTITLAP MQGVSLGQTS SSNTTLTPIA SAASIPAGTV TVNAAQLSSM PGLQTINLSA LGTSGIQVHP IQGLPLAIAN APGDHGAQLG LHGAGGDGIH DDTAGGEEGE NSPDAQPQAG RRTRREACTC PYCKDSEGRG SGDPGKKKQH ICHIQGCGKV YGKTSHLRAH LRWHTGERPF MCTWSYCGKR FTRSDELQRH KRTHTGEKKF ACPECPKRFM RSDHLSKHIK THQNKKGGPG VALSVGTLPL DSGAGSEGSG TATPSALITT NMVAMEAICP EGIARLANSG INVMQVADLQ SINISGNGF

Target Information

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HGNC:11205; Specificity protein 1; trans-acting transcription factor 1; transcription factor; transcription factor Sp-1; Transcription factor Sp1; transcriptional activator protein; unnamed protein product

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Gene Aliases: 1110003E12Rik; AA450830; AI845540; SP1; Sp1-1; TSFP1

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UniProt ID: (Human) P08047, (Mouse) O89090, (Rat) Q01714

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Entrez Gene ID: (Human) 6667, (Mouse) 20683, (Rat) 24790

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding histone acetyltransferase binding identical protein binding protein homodimerization activity histone deacetylase binding bHLH transcription factor binding sequence-specific DNA binding metal ion binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II repressing transcription factor binding nucleic acid binding protein C-terminus binding transcription factor binding enhancer binding transcription regulatory region DNA binding HMG box domain binding C2H2 zinc finger transcription factor
Process(es)
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of gene expression cellular response to insulin stimulus response to hydroperoxide cellular response to zinc ion starvation positive regulation of blood vessel endothelial cell migration positive regulation by host of viral transcription positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process cellular response to estrogen stimulus positive regulation of beta-amyloid formation cellular response to wortmannin positive regulation of hydrogen sulfide biosynthetic process positive regulation of vascular endothelial cell proliferation positive regulation of apoptotic signaling pathway ossification in utero embryonic development trophectodermal cell differentiation liver development embryonic placenta development transcription, DNA-templated transcription from RNA polymerase II promoter megakaryocyte differentiation lung development enucleate erythrocyte differentiation embryonic camera-type eye morphogenesis embryonic skeletal system development embryonic process involved in female pregnancy definitive hemopoiesis
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