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Proteintech
WNK1 Monoclonal Antibody (1B6A10), CoraLite® Plus 488
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Product Details
CL488-68149
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1B6A10
Immunogen
WNK1 fusion protein Ag28044
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSGGAAEKQ SSTPGSLFLS PPAPAPKNGS SSDSSVGEKL GAAAADAVTG RTEEYRRRRH TMDKDSRGAA ATTTTTEHRF FRRSVICDSN ATALELPGLP LSLPQPSIPA AVPQSAPPEP HREETVTATA TSQVAQQPPA AAAPGEQAVA GPAPSTVPSS TSKDRPVSQP SLVGSKEEPP PARSGSGGGS AKEPQEERSQ QQDDIEELET
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Erythrocyte 65 kDa protein; hWNK1; KIAA0344; Kinase deficient protein; MGC163339; MGC163341; p65; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; Serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; With no K
Gene Aliases: 6430573H23Rik; EG406236; HSAN2; HSN2; KDP; KIAA0344; mKIAA0344; p65; PPP1R167; PRKWNK1; PSK; WNK1
UniProt ID: (Human) Q9H4A3, (Rat) Q9JIH7, (Mouse) P83741
Entrez Gene ID: (Human) 65125, (Rat) 116477, (Mouse) 232341
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
phosphatase binding
protein kinase activator activity
protein serine kinase activity
molecular condensate scaffold activity
magnesium ion binding
chloride channel inhibitor activity
potassium channel inhibitor activity
protein serine/threonine kinase inhibitor activity
protein kinase inhibitor activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
regulation of sodium ion transport
positive regulation of systemic arterial blood pressure
protein phosphorylation
ion transport
cell volume homeostasis
cellular response to DNA damage stimulus
signal transduction
heart development
regulation of blood pressure
negative regulation of autophagy
negative regulation of sodium ion transport
regulation of mRNA export from nucleus
positive regulation of T cell chemotaxis
cellular chloride ion homeostasis
negative regulation of protein ubiquitination
negative regulation of cell-cell adhesion mediated by integrin
negative regulation of heterotypic cell-cell adhesion
intracellular signal transduction
sodium ion transmembrane transport
chemokine (C-C motif) ligand 21 signaling pathway
homeostatic process
protein insertion into ER membrane by stop-transfer membrane-anchor sequence
positive regulation of angiogenesis
neuron development
T cell receptor signaling pathway
negative regulation of small GTPase mediated signal transduction
potassium ion homeostasis
cation homeostasis
cellular hyperosmotic response
potassium ion transmembrane transport
negative regulation of pancreatic juice secretion
positive regulation of canonical Wnt signaling pathway
lymphocyte migration into lymph node
membraneless organelle assembly
regulation of sodium ion transmembrane transport
negative regulation of leukocyte cell-cell adhesion
negative regulation of protein localization to plasma membrane
positive regulation of mitotic cytokinesis
regulation of cation transmembrane transport
positive regulation of termination of RNA polymerase II transcription
cellular response to chemokine
negative regulation of phosphatase activity
negative regulation of kinase activity
protein autophosphorylation
regulation of cellular process
negative regulation of protein serine/threonine kinase activity
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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