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Proteintech
SREBF2 Recombinant Rabbit Monoclonal Antibody (240451A12), CoraLite® Plus 488
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Product Details
CL488-83403
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240451A12
Immunogen
SREBF2 fusion protein Ag28205
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: DYIKYLQQVN HKLRQENMVL KLANQKNKLL KGIDLGSLVD NEVDLKIEDF NQNVLLMSPP ASDSGSQAGF SPYSIDSEPG SPLLDDAKVK DEPDSPPVAL GMVDR
Target Information
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHd2; Class D basic helix-loop-helix protein 2; SREBF2; SREBP-2; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2; unnamed protein product
Gene Aliases: BHLHD2; SREBF2; SREBP-2; SREBP2
UniProt ID: (Human) Q12772
Entrez Gene ID: (Human) 6721
C-8 sterol isomerase activity
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
E-box binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
lipid metabolic process
steroid metabolic process
cholesterol metabolic process
regulation of Notch signaling pathway
cellular response to starvation
positive regulation of cholesterol storage
SREBP signaling pathway
cholesterol homeostasis
positive regulation of cholesterol biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
cellular response to low-density lipoprotein particle stimulus
cellular response to laminar fluid shear stress
negative regulation of cholesterol efflux
negative regulation of beta-amyloid clearance
regulation of mitophagy
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of protein targeting to mitochondrion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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