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Proteintech
JNK Monoclonal Antibody (1A12E1), CoraLite® Plus 488
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Product Details
CL48866210100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A12E1
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK-46; JNK3; JNK3A; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAPK 10; MAPK10; MAPK8; MGC50974; Mitogen-activated protein kinase 8; MK10; OTTHUMP00000019552; p493F12; p54bSAPK; Phospho-JNK; PRKM10; protein kinase JNK1; SAPK1c; stress-activated protein kinase 1; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; unnamed protein product
Gene Aliases: JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; MAPK8; PRKM8; SAPK1; SAPK1C
UniProt ID: (Human) P45983
Entrez Gene ID: (Human) 5599
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
JUN kinase activity
MAP kinase activity
protein binding
ATP binding
kinase activity
transferase activity
enzyme binding
protein phosphatase binding
histone deacetylase regulator activity
histone deacetylase binding
protein serine kinase activity
protein serine/threonine kinase binding
MAPK cascade
double-strand break repair
protein phosphorylation
response to oxidative stress
JNK cascade
JUN phosphorylation
response to UV
response to mechanical stimulus
positive regulation of gene expression
regulation of macroautophagy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of cyclase activity
positive regulation of cell killing
negative regulation of protein binding
regulation of protein localization
cellular response to amino acid starvation
cellular response to oxidative stress
cellular response to reactive oxygen species
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
regulation of mRNA stability
NLRP3 inflammasome complex assembly
rhythmic process
positive regulation of protein metabolic process
stress-activated MAPK cascade
mRNA destabilization
protein poly-ADP-ribosylation
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular senescence
energy homeostasis
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of establishment of protein localization to mitochondrion
protein localization to site of double-strand break
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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