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Proteintech
c-Cbl Monoclonal Antibody (2F6D1), CoraLite® Plus 750
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Product Details
CL750-66576
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2F6D1
Immunogen
c-Cbl fusion protein Ag23033
Conjugate
Excitation/Emission Max
755/780 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LPPVPSSRL GDSWLPRPIP KVPVSAPSSS DPWTGRELTN RHSLPFSLPS QMEPRPDVPR LGSTFSLDTS MSMNSSPLVG PECDHPKIKP SSSANAIYSL AARPLPVPKL PPGEQCEGEE DTEYMTPSSR PLRPLDTSQS SRACDCDQQI DSCTYEAMYN IQSQAPSITE SSTFGEGNLA AAHANTGPEE SENEDDGYDV PKPPVPAVLA RRTLSDISNA SSSFGWLSLD GDPTTNVTEG SQVPERPPKP FPRRINSERK AGSCQQGSGP AASAATASPQ LSSEIENLMS QGYSYQDIQK ALVIAQNNIE MAKNILREFV SISSPAHVAT
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-cbl; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
Gene Aliases: 4732447J05Rik; C-CBL; CBL; Cbl-2; CBL2; FRA11B; NSLL; RNF55
UniProt ID: (Human) P22681, (Mouse) P22682
Entrez Gene ID: (Human) 867, (Mouse) 12402
phosphotyrosine binding
ubiquitin-protein transferase activity
calcium ion binding
protein binding
zinc ion binding
transferase activity
SH3 domain binding
protein kinase binding
receptor tyrosine kinase binding
phosphatidylinositol 3-kinase regulatory subunit binding
cadherin binding
metal ion binding
ephrin receptor binding
ubiquitin protein ligase activity
protein tyrosine kinase binding
signal transducer activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ligase
metabolite interconversion enzyme
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
signal transduction
cell surface receptor signaling pathway
male gonad development
response to gamma radiation
response to activity
protein ubiquitination
cytokine-mediated signaling pathway
regulation of signaling
regulation of Rap protein signal transduction
response to testosterone
cellular response to platelet-derived growth factor stimulus
negative regulation of epidermal growth factor receptor signaling pathway
response to starvation
negative regulation of apoptotic process
mast cell degranulation
response to ethanol
positive regulation of epidermal growth factor receptor signaling pathway
viral entry into host cell
positive regulation of receptor-mediated endocytosis
protein autoubiquitination
positive regulation of protein kinase B signaling
ubiquitin-dependent endocytosis
cellular response to hypoxia
regulation of intracellular signal transduction
cellular response to nerve growth factor stimulus
regulation of platelet-derived growth factor receptor-alpha signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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