This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: NLENGELCMN SAQCKSNCCQ HSSALGLARC TSMASENSEC SVKTLYGIYY KCPCERGLTC EGDKTIVGSI TNTNFGICHD AGR
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 72%.
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COL; Colipase; colipase, pancreatic; pancreatic colipase preproprotein
Gene Aliases: CLPS
UniProt ID: (Human) P04118
Entrez Gene ID: (Human) 1208
Molecular Function: protein-binding activity modulator