Immunogen sequence: VGDKKGKIVD AVIQEHQPSV LLELGAYCGY SAVRMARLLS PGARLITIEI NPDCAAITQR MVDFAGVKDK VTLVVGASQD IIPQLKKKYD VDTLDMVFLD HWKDRYLPDT LLLEECGLLR KGTVLLADNV ICPGAPDFLA HVRGSSCFEC THYQSFLEYR EVVDGLEKAI YKGPGSEAGP; Positive Samples: MCF-7, HT-29, THP-1, A-431, HepG2, Mouse liver; Cellular Location: Cell membrane, Cytoplasm, Extracellular side, Single-pass type II membrane protein
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
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Protein Aliases: Catechol O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; epididymis secretory sperm binding protein Li 98n; testicular tissue protein Li 42
Gene Aliases: COMT; Comt1; D16Wsu103e; D330014B15Rik; HEL-S-98n