PA1-41634 detects Exportin-1 in chimpanzee, bovine, canine and human samples.
This antibody is predicted to cross react with mouse and rat samples based on sequence homology.
Suggested positive control: Jurkat whole cell lysate.
Nuclear transport receptors of karyopherin/importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-1, a human homolog of yeast CRM1, is a novel karyopherin export receptor that mediates leucine-rich NES-dependent protein export. It interacts with RanGTP through its Ran-binding domain and also with nucleoporins including Nup214, Nup50, Nup42 and Nup159 during the process of exporting NES-containing proteins. It mediates the export of many cellular and viral proteins and ribonucleoproteins including HIV Rev Protein, ERK3, PKI, IRF-5, Cyclin-B, MAPKK, MAPKAP kinase 2, Snurportin, Cap-binding protein, and certain U snRNAs. Reports suggest exportin-1 also has a role in the regulation of NFAT and AP-1.
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Protein Aliases: chromosome region maintenance 1 homolog; Chromosome region maintenance 1 protein homolog; CRM1; Exp1; exportin 1 (CRM1 homolog, yeast); Exportin-1; exportin-1 (required for chromosome region maintenance); XPO1
Gene Aliases: BOS_11697; CRM1; emb; exp1; XPO1
UniProt ID: (Human) O14980
Molecular Function: receptor