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Invitrogen
CYFIP2 Polyclonal Antibody
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Product Details
PA5-67174
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CYFIP2. Recombinant protein control fragment (Product #RP-107817).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STQACQWSPRA LFHPTGGTQG RRGCRSLLY
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 40%.
Target Information
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytoplasmic FMR1-interacting protein 2; inducible protein; p53-inducible protein 121; PIR121; unnamed protein product
Gene Aliases: CYFIP2; DEE65; EIEE65; KIAA1168; PIR121
UniProt ID: (Human) Q96F07
Entrez Gene ID: (Human) 26999
cell morphogenesis
apoptotic process
cell adhesion
axon guidance
cell projection assembly
regulation of actin filament polymerization
neuron projection development
positive regulation of proteolysis
positive regulation of neurotrophin TRK receptor signaling pathway
dendrite extension
cell-cell adhesion
regulation of postsynapse assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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