Proteintech

Casein Kinase 1 delta Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (5)

Casein Kinase 1 delta Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

Casein Kinase 1 delta Antibody (14388-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using CSNK1D antibody 14388-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Casein Kinase 1 delta Antibody in Western Blot (WB)

Casein Kinase 1 delta Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14388-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Casein Kinase 1 delta Fusion Protein Ag5856 (103-373 aa encoded by BC003558)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KTVLLLADQ MISRIEYIHS KNFIHRDVKP DNFLMGLGKK GNLVYIIDFG LAKKYRDART HQHIPYRENK NLTGTARYAS INTHLGIEQS RRDDLESLGY VLMYFNLGSL PWQGLKAATK RQKYERISEK KMSTPIEVLC KGYPSEFATY LNFCRSLRFD DKPDYSYLRQ LFRNLFHRQG FSYDYVFDWN MLKFGASRAA DDAERERRDR EERLRHSRNP ATRGLPSTAS GRLRGTQEVA PPTPLTPTSH TANTSPRPVS GMERERKVSM RL (103-373 aa encoded by BC003558)

Target Information

CSNK1D (CK1 delta), a serine/threonine kinase, plays a critical role in Wnt/beta-catenin signaling pathway. This pathway is important in both development and cancer. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for CK1 delta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 EST 2023

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 EST 2023

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 EST 2023

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 EST 2023

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.

The Journal of cell biology

Deng X,Sun X,Yue W,Duan Y,Hu R,Zhang K,Ni J,Cui J,Wang Q,Chen Y,Li A,Fang Y

Mon Jan 03 00:00:00 EST 2022

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.

Molecular cancer

Jiang Q,Zheng N,Bu L,Zhang X,Zhang X,Wu Y,Su Y,Wang L,Zhang X,Ren S,Dai X,Wu D,Xie W,Wei W,Zhu Y,Guo J

Thu Aug 05 00:00:00 EDT 2021

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.

Oncogene

Lu Y,Li X,Liu H,Xue J,Zeng Z,Dong X,Zhang T,Wu G,Yang K,Xu S

Mon Feb 01 00:00:00 EST 2021

Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion.

Frontiers in cell and developmental biology

Li Y,Chen X,Xiong Q,Chen Y,Zhao H,Tahir M,Song J,Zhou B,Wang J

Mon Sep 28 00:00:00 EDT 2020

Mitotic ER Exit Site Disassembly and Reassembly Are Regulated by the Phosphorylation Status of TANGO1.

Developmental cell

Maeda M,Komatsu Y,Saito K

Mon Oct 26 00:00:00 EDT 2020

Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis.

Frontiers in pharmacology

Keenan CR,Langenbach SY,Jativa F,Harris T,Li M,Chen Q,Xia Y,Gao B,Schuliga MJ,Jaffar J,Prodanovic D,Tu Y,Berhan A,Lee PVS,Westall GP,Stewart AG

Thu Oct 01 00:00:00 EDT 2020

Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis.

Frontiers in pharmacology

Keenan CR,Langenbach SY,Jativa F,Harris T,Li M,Chen Q,Xia Y,Gao B,Schuliga MJ,Jaffar J,Prodanovic D,Tu Y,Berhan A,Lee PVS,Westall GP,Stewart AG

Thu Oct 01 00:00:00 EDT 2020

Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.

Cell cycle (Georgetown, Tex.)

Qi ST,Wang ZB,Huang L,Liang LF,Xian YX,Ouyang YC,Hou Y,Sun QY,Wang WH

Wed Mar 02 00:00:00 EST 2016

Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.

Cell cycle (Georgetown, Tex.)

Qi ST,Wang ZB,Huang L,Liang LF,Xian YX,Ouyang YC,Hou Y,Sun QY,Wang WH

Wed Mar 02 00:00:00 EST 2016

DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.

Molecular and cellular biology

Chen H,Ma H,Inuzuka H,Diao J,Lan F,Shi YG,Wei W,Shi Y

Fri Mar 01 00:00:00 EST 2013

DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.

Molecular and cellular biology

Chen H,Ma H,Inuzuka H,Diao J,Lan F,Shi YG,Wei W,Shi Y

Fri Mar 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: casein kinase 1; casein kinase 1, delta; Casein kinase I isoform delta; CK1d; CK1delta; CKI-delta; CKId; HGNC:2452; Tau-protein kinase CSNK1D

View more View less

Gene Aliases: 1200006A05Rik; AA409348; ASPS; CKIdelta; CSNK1D; D930010H05Rik; FASPS2; HCKID

View more View less

UniProt ID: (Human) P48730, (Rat) Q06486, (Mouse) Q9DC28

View more View less

Entrez Gene ID: (Human) 1453, (Rat) 64462, (Mouse) 104318

View more View less

Function(s)

glycoprotein binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding peptide binding tau-protein kinase activity phosphoprotein binding cadherin binding involved in cell-cell adhesion nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

Process(es)

G2/M transition of mitotic cell cycle positive regulation of protein phosphorylation DNA repair rRNA processing protein phosphorylation endocytosis microtubule nucleation Golgi organization signal transduction regulation of cell shape Wnt signaling pathway peptidyl-serine phosphorylation positive regulation of proteasomal ubiquitin-dependent protein catabolic process circadian regulation of gene expression protein localization to Golgi apparatus nonmotile primary cilium assembly regulation of circadian rhythm COPII vesicle coating spindle assembly protein localization to cilium protein localization to centrosome positive regulation of canonical Wnt signaling pathway cell-cell adhesion cellular response to nerve growth factor stimulus positive regulation of non-canonical Wnt signaling pathway mitotic cell cycle phosphorylation rhythmic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Casein Kinase 1 delta Polyclonal Antibody

Casein Kinase 1 delta Antibody (14388-1-AP) in ICC/IF

Product Details

14388-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!