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Exalpha

DAP12 Polyclonal Antibody

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Product Details

X1588P

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunoprecipitation (IP)

2-4 µg/mg
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant DAP12 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-2 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

PBS

Contains

0.08% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: MCF-7 and T47D cells.

The antibody reacts with the extracellular 12-mer GVTSAPDTRPAP epitope of the MUC-1 tandem repeat.Antibody can be used for immunohistochemistry on frozen and paraffin embedded tissues and ELISA.

Target Information

DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNAX adaptor protein 12; DNAX-activation protein 12; KAR-associated protein; killer cell activating receptor associated protein; Killer-activating receptor-associated protein; membrane protein; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein; TYROBP; unnamed protein product

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Gene Aliases: DAP12; KARAP; Ly83; PLOSL; PLOSL1; TYROBP

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UniProt ID: (Human) O43914, (Mouse) O54885

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Entrez Gene ID: (Human) 7305, (Mouse) 22177

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Function(s)
receptor binding protein binding protein binding, bridging identical protein binding protein homodimerization activity metal ion binding binding, bridging scaffold/adaptor protein
Process(es)
negative regulation of cytokine production stimulatory killer cell immunoglobulin-like receptor signaling pathway stimulatory C-type lectin receptor signaling pathway natural killer cell mediated immunity immune effector process myeloid leukocyte activation macrophage activation involved in immune response microglial cell activation involved in immune response neutrophil activation involved in immune response T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell immune system process positive regulation of immune system process defense response immune response cellular defense response signal transduction cell surface receptor signaling pathway integrin-mediated signaling pathway positive regulation of gene expression actin cytoskeleton organization osteoclast differentiation negative regulation of B cell proliferation forebrain development negative regulation of type I interferon production positive regulation of type I interferon production negative regulation of interleukin-10 production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation negative regulation of transforming growth factor beta1 production positive regulation of superoxide anion generation positive regulation of macrophage fusion intracellular signal transduction apoptotic cell clearance response to axon injury protein stabilization regulation of biological quality semaphorin-plexin signaling pathway beta-amyloid clearance negative regulation of long-term synaptic potentiation positive regulation of receptor localization to synapse positive regulation of microglial cell mediated cytotoxicity cellular response to beta-amyloid positive regulation of protein localization to cell surface regulation of osteoclast development positive regulation of osteoclast development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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