Search
Proteintech
DRD4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
28094-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DRD4 Fusion Protein Ag26930
Conjugate
Form
Liquid
Concentration
533 µg/mL
Amount
79.95 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4; seven transmembrane helix receptor
Gene Aliases: AW125663; D4DR; D4R; Drd-4; DRD4
UniProt ID: (Human) P21917, (Mouse) P51436
Entrez Gene ID: (Pig) 100512329, (Human) 1815, (Mouse) 13491
dopamine neurotransmitter receptor activity, coupled via Gi/Go
G-protein coupled receptor activity
dopamine neurotransmitter receptor activity
G-protein coupled serotonin receptor activity
protein binding
potassium channel regulator activity
SH3 domain binding
neurotransmitter receptor activity
dopamine binding
identical protein binding
metal ion binding
epinephrine binding
norepinephrine binding
signal transducer activity
drug binding
G-protein coupled amine receptor activity
G-protein coupled receptor
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
cellular calcium ion homeostasis
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
chemical synaptic transmission
adult locomotory behavior
adult behavior
response to histamine
social behavior
regulation of dopamine metabolic process
fear response
regulation of circadian rhythm
positive regulation of MAPK cascade
behavioral response to cocaine
behavioral response to ethanol
rhythmic process
arachidonic acid secretion
negative regulation of protein secretion
regulation of transport
positive regulation of dopamine uptake involved in synaptic transmission
inhibitory postsynaptic potential
phospholipase C-activating dopamine receptor signaling pathway
regulation of primary metabolic process
G protein-coupled serotonin receptor signaling pathway
regulation of postsynaptic neurotransmitter receptor internalization
activation of MAPK activity
negative regulation of adenylate cyclase activity
dopamine receptor signaling pathway
sensory perception of chemical stimulus
short-term memory
associative learning
olfactory learning
negative regulation of cAMP biosynthetic process
positive regulation of sodium:proton antiporter activity
positive regulation of kinase activity
regulation of neurotransmitter secretion
modulation of synaptic transmission
regulation of calcium-mediated signaling
positive regulation of penile erection
negative regulation of voltage-gated calcium channel activity
positive regulation of excitatory postsynaptic potential
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support