EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.
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Protein Aliases: Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor Edg-3; S1P receptor EDG3; S1P receptor S1P3; sphingosine; Sphingosine 1-phosphate receptor 3; Sphingosine 1-phosphate receptor Edg-3
Gene Aliases: AI132464; EDG-3; EDG3; LPB3; S1P3; S1PR3
Molecular Function: G-protein coupled receptor