Immunogen sequence: TKPSSSLSIG SIISKSPLAS PAPQSTSFFS PSFSLGLGDD SFPIAGIYDT TTDNKCSIKT AVAKNMLDPI TGQKLLEAQA ATGGIVDLLS RERYSVHKAM ERGLIENTST QRLLNAQKAF TGIEDPVTKK RLSVGEAVQK GWMPRESVLP HLQVQHLTGG LIDPKRTGRI PIQQALLSGM ISEELAQLLQ DESSYEKDLT DPISKERLSY KEAMGRCRKD PLSGLLLLPA ALEGYRCYRS ASPTVPRSLR; Positive Samples: HeLa, Mouse lung, Rat lung; Cellular Location: Cell junction, Cornified envelope, Cytoplasm, cytoskeleton, desmosome
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.
Protein Aliases: 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; 210-kD protein; 210kDa protein; Envoplakin; p210
Gene Aliases: EVPK; EVPL
Molecular Function: intermediate filament binding protein