Immunogen sequence: RKAGLAHLYG IAGSVNVTGD EVKKLDVLSN SLVINMVQSS YSTCVLVSEE NKDAIITAKE KRGKYVVCFD PLDG
This product detects both FBP1 and FBP2, which are 80% homologous. The antigen sequence is a 100% match to FBP2 and the product has been validated against FBP1.
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 93%.
FBP1 and FBP2 are gluconeogenesis regulatory enzymes which catalyze the hydrolosis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBP1; FBP2; FBPase 1; FBPase 2; Fructose-1,6-bisphosphatase 1; fructose-1,6-bisphosphatase 2; Fructose-1,6-bisphosphatase isozyme 2; growth-inhibiting protein 17; hexosediphosphatase; Liver FBPase; Muscle FBPase; muscle fructose-bisphosphatase
Gene Aliases: FBP; FBP1; FBP2