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Nordic
Factor VII Polyclonal Antibody
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Product Details
RAHU-FVII
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human Factor VII
Conjugate
Form
Lyophilized
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The antiSerum does not cross-react with any other Human plasma proteins as tested in gel-diffusion techniques. Interspecies cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail, however in double radial immunodiffusion a reaction with Rhesus Monkey has been observed.
In immunoelectrophoresis in agarose-plates use 2 µL human plasma or equivalent against 120 µL antiserum. In double radial immunodiffusion use a rosette arrangement with 10 µL antiserum in 3 mm diameter center well and 2 µL plasma samples (neat and serially diluted) in 2 mm diameter peripheral wells. In electroimmunodiffusion the antiserum concentration required in the gel is normally between 1 and 2%. The amount of Factor VII precipitated by 1 mL antiserum is approximately 100 U. One Unit of Factor VII is defined as the amount present in 1 mL normal plasma. On the average this corresponds to 1 µg/mL.
Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). If a slight precipitation occurs upon storage, this should be removed by centrifugation and will not affect the performance of the product. Diluted solutions should be stored at 4°C, not refrozen, and preferably used the same day.
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; preprofactor VIIb; Proconvertin; Serum prothrombin conversion accelerator; SPCA; unnamed protein product
Gene Aliases: F7; SPCA
UniProt ID: (Human) P08709
Entrez Gene ID: (Human) 2155
response to hypoxia
positive regulation of leukocyte chemotaxis
proteolysis
response to stress
blood coagulation
hemostasis
circadian rhythm
response to hormone
response to carbon dioxide
positive regulation of platelet-derived growth factor receptor signaling pathway
protein processing
positive regulation of blood coagulation
positive regulation of cell migration
organ regeneration
response to nutrient levels
positive regulation of TOR signaling
response to estradiol
response to vitamin K
response to genistein
response to estrogen
regulation of body fluid levels
positive regulation of positive chemotaxis
response to growth hormone
response to cholesterol
response to thyroid hormone
response to thyroxine
response to Thyroid stimulating hormone
response to 2,3,7,8-tetrachlorodibenzodioxine
response to astaxanthin
response to thyrotropin-releasing hormone
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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