Proteintech

Frizzled 7 Polyclonal Antibody

Frizzled 7 Antibody in Western Blot (WB)

FIGURE: 1 / 4

Frizzled 7 Antibody (16974-1-AP) in WB

Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 16974-1-AP (Frizzled 7 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Frizzled 7 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16974-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Frizzled 7 Fusion Protein Ag9446 (33-257 aa encoded by BC015915)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QPYHGEKGI SVPDHGFCQP ISIPLCTDIA YNQTILPNLL GHTNQEDAGL EVHQFYPLVK VQCSPELRFF LCSMYAPVCT VLDQAIPPCR SLCERARQGC EALMNKFGFQ WPERLRCENF PVHGAGEICV GQNTSDGSGG PGGGPTAYPT APYLPDLPFT ALPPGASDGR GRPAFPFSCP RQLKVPPYLG YRFLGERDCG APCEPGRANG LMYFKEEERR FARLWV (33-257 aa encoded by BC015915)

Target Information

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

m⁶ A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation.

Advanced materials (Deerfield Beach, Fla.)

You Q,Wang F,Du R,Pi J,Wang H,Huo Y,Liu J,Wang C,Yu J,Yang Y,Zhu L

Wed Feb 01 00:00:00 UTC 2023

Frontiers in cardiovascular medicine

Zheng Y,Qi B,Gao W,Qi Z,Liu Y,Wang Y,Feng J,Cheng X,Luo Z,Li T

Tue Jul 19 00:00:00 UTC 2022

Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.

Cell death discovery

Xu H,Xia H,Zhou S,Tang Q,Bi F

Fri Feb 26 00:00:00 UTC 2021

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.

Cancer research

Pi J,Wang W,Ji M,Wang X,Wei X,Jin J,Liu T,Qiang J,Qi Z,Li F,Liu Y,Ma Y,Si Y,Huo Y,Gao Y,Chen Y,Dong L,Su R,Chen J,Rao S,Yi P,Yu S,Wang F,Yu J

Sat May 15 00:00:00 UTC 2021

Targeting Frizzled-7 Decreases Stemness and Chemotherapeutic Resistance in Gastric Cancer Cells by Suppressing Myc Expression.

Medical science monitor : international medical journal of experimental and clinical research

Cheng Y,Li L,Pan S,Jiang H,Jin H

Sat Nov 16 00:00:00 UTC 2019

Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway.

Cell death and differentiation

Lo RC,Leung CO,Chan KK,Ho DW,Wong CM,Lee TK,Ng IO

Wed Aug 01 00:00:00 UTC 2018

Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway.

Cell death and differentiation

Lo RC,Leung CO,Chan KK,Ho DW,Wong CM,Lee TK,Ng IO

Wed Aug 01 00:00:00 UTC 2018

Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.

International journal of molecular medicine

Xing F,Yi WJ,Miao F,Su MY,Lei TC

Sun Apr 01 00:00:00 UTC 2018

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B.

Frontiers in microbiology

Schöttelndreier D,Seeger K,Grassl GA,Winny MR,Lindner R,Genth H

Thu Oct 01 00:00:00 UTC 2020

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B.

Frontiers in microbiology

Schöttelndreier D,Seeger K,Grassl GA,Winny MR,Lindner R,Genth H

Thu Oct 01 00:00:00 UTC 2020

Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia.

Theranostics

Liu W,Zhang L,Xuan K,Hu C,Li L,Zhang Y,Jin F,Jin Y

Mon Sep 09 00:00:00 UTC 2019

Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia.

Theranostics

Liu W,Zhang L,Xuan K,Hu C,Li L,Zhang Y,Jin F,Jin Y

Mon Sep 09 00:00:00 UTC 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Molecular systems biology

Sokolina K,Kittanakom S,Snider J,Kotlyar M,Maurice P,Gandía J,Benleulmi-Chaachoua A,Tadagaki K,Oishi A,Wong V,Malty RH,Deineko V,Aoki H,Amin S,Yao Z,Morató X,Otasek D,Kobayashi H,Menendez J,Auerbach D,Angers S,Pržulj N,Bouvier M,Babu M,Ciruela F,Jockers R,Jurisica I,Stagljar I

Wed Mar 15 00:00:00 UTC 2017

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Molecular systems biology

Wed Mar 15 00:00:00 UTC 2017

Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathway.

International journal of oncology

Sun Q,Wang R,Luo J,Wang P,Xiong S,Liu M,Cheng B

Wed Oct 01 00:00:00 UTC 2014

Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathway.

International journal of oncology

Sun Q,Wang R,Luo J,Wang P,Xiong S,Liu M,Cheng B

Wed Oct 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7

View more View less

Gene Aliases: Fz7; FZD7; FzE3

View more View less

UniProt ID: (Human) O75084, (Mouse) Q61090

View more View less

Entrez Gene ID: (Human) 8324, (Mouse) 14369

View more View less

Function(s)

G-protein coupled receptor activity frizzled binding protein binding Wnt-protein binding PDZ domain binding Wnt-activated receptor activity signal transducer activity transmembrane signaling receptor activity transmembrane signal receptor

Process(es)

regulation of transcription, DNA-templated G-protein coupled receptor signaling pathway negative regulation of cell-substrate adhesion skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration stem cell population maintenance neuron differentiation T cell differentiation in thymus substrate adhesion-dependent cell spreading regulation of catenin import into nucleus non-canonical Wnt signaling pathway via JNK cascade positive regulation of phosphorylation negative regulation of ectodermal cell fate specification positive regulation of transcription, DNA-templated positive regulation of JNK cascade somatic stem cell division positive regulation of epithelial cell proliferation involved in wound healing canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway mesenchymal to epithelial transition cellular response to retinoic acid signal transduction cell surface receptor signaling pathway multicellular organism development Wnt signaling pathway non-canonical Wnt signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Frizzled 7 Polyclonal Antibody

Frizzled 7 Antibody (16974-1-AP) in WB

Product Details

16974-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!