Proteintech

Frizzled 7 Polyclonal Antibody

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Frizzled 7 Antibody in Western Blot (WB) — Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 16974-1-AP (Frizzled 7 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Frizzled 7 Antibody in Immunoprecipitation (IP) — IP result of anti-Frizzled 7 (IP:16974-1-AP, 4ug; Detection:16974-1-AP 1:600) with mouse skeletal muscle tissue lysate 2200ug.

Product Details

16974-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 4 publications 4 publications
Immunoprecipitation (IP)	0.5-4.0 µg	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Frizzled 7 Fusion Protein Ag9446 (33-257 aa encoded by BC015915) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.33 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: QPYHGEKGI SVPDHGFCQP ISIPLCTDIA YNQTILPNLL GHTNQEDAGL EVHQFYPLVK VQCSPELRFF LCSMYAPVCT VLDQAIPPCR SLCERARQGC EALMNKFGFQ WPERLRCENF PVHGAGEICV GQNTSDGSGG PGGGPTAYPT APYLPDLPFT ALPPGASDGR GRPAFPFSCP RQLKVPPYLG YRFLGERDCG APCEPGRANG LMYFKEEERR FARLWV (33-257 aa encoded by BC015915)

Target Information

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B.

Frontiers in microbiology

Schöttelndreier D,Seeger K,Grassl GA,Winny MR,Lindner R,Genth H

Thu Oct 01 00:00:00 EDT 2020

Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia.

Theranostics

Liu W,Zhang L,Xuan K,Hu C,Li L,Zhang Y,Jin F,Jin Y

Mon Sep 09 00:00:00 EDT 2019

Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway.

Cell death and differentiation

Lo RC,Leung CO,Chan KK,Ho DW,Wong CM,Lee TK,Ng IO

Wed Aug 01 00:00:00 EDT 2018

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Molecular systems biology

Sokolina K,Kittanakom S,Snider J,Kotlyar M,Maurice P,Gandía J,Benleulmi-Chaachoua A,Tadagaki K,Oishi A,Wong V,Malty RH,Deineko V,Aoki H,Amin S,Yao Z,Morató X,Otasek D,Kobayashi H,Menendez J,Auerbach D,Angers S,Pržulj N,Bouvier M,Babu M,Ciruela F,Jockers R,Jurisica I,Stagljar I

Wed Mar 15 00:00:00 EDT 2017

Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathway.

International journal of oncology

Sun Q,Wang R,Luo J,Wang P,Xiong S,Liu M,Cheng B

Wed Oct 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7

Gene Aliases: Fz7; FZD7; FzE3

UniProt ID: (Human) O75084, (Mouse) Q61090

Entrez Gene ID: (Human) 8324, (Mouse) 14369, (Rat) 100360552

Molecular Function: transmembrane signal receptor