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Proteintech
Frizzled 7 Polyclonal Antibody
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Product Details
16974-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Frizzled 7 Fusion Protein Ag9446 (33-257 aa encoded by BC015915)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QPYHGEKGI SVPDHGFCQP ISIPLCTDIA YNQTILPNLL GHTNQEDAGL EVHQFYPLVK VQCSPELRFF LCSMYAPVCT VLDQAIPPCR SLCERARQGC EALMNKFGFQ WPERLRCENF PVHGAGEICV GQNTSDGSGG PGGGPTAYPT APYLPDLPFT ALPPGASDGR GRPAFPFSCP RQLKVPPYLG YRFLGERDCG APCEPGRANG LMYFKEEERR FARLWV (33-257 aa encoded by BC015915)
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7
Gene Aliases: Fz7; FZD7; FzE3
UniProt ID: (Human) O75084, (Mouse) Q61090
Entrez Gene ID: (Human) 8324, (Mouse) 14369
regulation of transcription, DNA-templated
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of cell-substrate adhesion
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Wnt signaling pathway
stem cell population maintenance
neuron differentiation
T cell differentiation in thymus
substrate adhesion-dependent cell spreading
non-canonical Wnt signaling pathway
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of MAPK cascade
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
somatic stem cell division
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
mesenchymal to epithelial transition
regulation of canonical Wnt signaling pathway
cellular response to retinoic acid
negative regulation of cardiac muscle cell differentiation
multicellular organism development
regulation of catenin import into nucleus
non-canonical Wnt signaling pathway via JNK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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