Keep as concentrated solution.
Positive Control: SK-N-SH, mouse brain, rat brain, human GAD1-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 67 kDa glutamic acid decarboxylase; 67 kDa glutamic acid decarboxylase antibody; 67kDa) antibody; FLJ45882 antibody; GAD antibody; GAD-67; GAD-67 antibody; GAD1 antibody; Glutamate decarboxylase 1; glutamate decarboxylase 1 (brain; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1 antibody; glutamate decarboxylase 1 variant GAD67NT; Glutamate decarboxylase 67 kDa isoform; glutamate decarboxylase 67 kDa isoform antibody; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); glutamic acid decarboxylase 1; SCP antibody
Gene Aliases: CPSQ1; EP10; GAD; Gad-1; GAD1; GAD25; GAD44; GAD67; SCP