PA5-27480 targets GRK2 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-27480 immunogen is recombinant fragment corresponding to a region within amino acids 477 and 689 of Human GRK2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
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Protein Aliases: adrenergic beta receptor kinase 1; adrenergic, beta, receptor kinase 1; BARK1; Beta-adrenergic receptor kinase 1; beta-AR kinase-1; Beta-ARK-1; BETA-ARK1; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; GRK2
Gene Aliases: Adrbk-1; ADRBK1; BARK; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GRK2