Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
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Protein Aliases: glutathione S-alkyltransferase; glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase; glutathione S-aralkyltransferase M2; glutathione S-aryltransferase; glutathione S-aryltransferase M2; glutathione S-transferase 4; Glutathione S-transferase GT8.7; glutathione S-transferase M1; glutathione S-transferase M2; glutathione S-transferase M2 (muscle); Glutathione S-transferase Mu 1; Glutathione S-transferase Mu 2; Glutathione S-transferase pmGT2; Glutathione S-transferase Yb-1; glutathione S-transferase Yb-1 subunit; Glutathione S-transferase Yb-2; glutathione S-transferase Yb2 subunit; glutathione-S-transferase mu type 1 (Yb1); Glutathione-S-transferase mu type 2 (Yb2); glutathione-S-transferase, mu 1; glutathione-S-transferase, mu 2; glutathione-S-transferase, mu type 1 (Yb1); Glutathione-S-transferase, mu type 2 (Yb2); GST 1-1; GST 3-3; GST 4-4; GST 5-5; GST class-mu 1; GST class-mu 2; GST HB subunit 4; GST Yb1; GST Yb2; GST, muscle; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GSTM2-2; GTH4; HB subunit 4; MGC117303; MGC26563; pmGT10; S-(hydroxyalkyl)glutathione lyase; S-(hydroxyalkyl)glutathione lyase M2
Gene Aliases: GST1; GST4; GSTA3; GSTA4; Gstb-1; Gstb-2; Gstb1; Gstb2; GSTM; GSTM1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GSTM2; GSTM2-2; GTH4; GTHMUS; GTM1; H-B; MU; MU-1