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Invitrogen

Galectin 3 Polyclonal Antibody

View all (139) Galectin 3 antibodies

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Galectin 3 Polyclonal Antibody

Product Details

PA5-119672

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein within Human Galectin 3 aa 1-180.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913245

Product Specific Information

Positive Control: SiHa, mouse colon tissue, A431, LOVO, rat lung tissue, human colon cancer tissue, mouse testis tissue.

Subcellular Location: Cytoplasm, Nucleus, Secreted.

Target Information

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 35 kDa lectin; advanced glycation end-product receptor 3; Carbohydrate-binding protein 35; CBP 35; CBP-30; epididymis secretory sperm binding protein; epithelial-specific lectin; epsilon BP; Gal-3; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; Galectin-3; Galectin3; IgE binding protein; IgE-binding protein; L-29; L-31; L-34 galactoside-binding lectin; Laminin-binding protein; lectin galactoside-binding soluble 3 protein; Lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside-binding, soluble, 3; LGALS3; MAC-2 antigen; unnamed protein product

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Gene Aliases: AGE-R3; CBP30; CBP35; gal-3; GAL3; GALBP; GALIG; GBP; L-34; L31; LGALS2; LGALS3; Mac-2; MAC2

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UniProt ID: (Human) P17931, (Rat) P08699

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Entrez Gene ID: (Human) 3958, (Mouse) 16854, (Rat) 83781

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Function(s)
RNA binding protein phosphatase inhibitor activity protein binding IgE binding protein phosphatase binding carbohydrate binding receptor inhibitor activity chemoattractant activity laminin binding disaccharide binding oligosaccharide binding molecular condensate scaffold activity receptor ligand inhibitor activity Fc-gamma receptor I complex binding poly(A) RNA binding monosaccharide binding advanced glycation end-product receptor activity extracellular matrix protein
Process(es)
immune system process monocyte chemotaxis mRNA processing RNA splicing cell differentiation neutrophil chemotaxis epithelial cell differentiation positive regulation of protein complex assembly killing of cells of other organism regulation of T cell proliferation innate immune response negative regulation of endocytosis eosinophil chemotaxis macrophage chemotaxis negative regulation of T cell receptor signaling pathway positive chemotaxis NK T cell activation negative regulation of NK T cell activation antimicrobial humoral immune response mediated by antimicrobial peptide regulation of T cell apoptotic process mononuclear cell migration positive regulation of mononuclear cell migration positive regulation of calcium ion import regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein localization to plasma membrane negative regulation of immunological synapse formation negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of dendritic cell differentiation negative regulation of extrinsic apoptotic signaling pathway skeletal system development signal transduction positive regulation of cell proliferation positive regulation of serotonin secretion extracellular matrix organization negative regulation of apoptotic process positive regulation of angiogenesis negative regulation of cell proliferation in bone marrow
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