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Invitrogen
HEXA Polyclonal Antibody
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FIGURE: 1 / 1
HEXA Antibody (PA5-79358) in WB
Western blot analysis of HEXA in, Lane 1: human Hela whole cell lysates, Lane 2: human 293T whole cell lysates, Lane 3: human Caco-2 whole cell lysates, Lane 4: human THP-1 whole cell lysates, Lane 5: human HepG2 whole cell lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. The ... View More
Product Details
PA5-79358
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human HEXA (513-529aa QAQPLNVGFCEQEFEQT).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human 293T whole cell, human Caco-2 whole cell, human THP-1 whole cell, human HepG2 whole cell.
Target Information
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-hexosaminidase; Beta-hexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; EC 3.2.1; EC 3.2.1.52; HEXA; hexosaminidase A (alpha polypeptide); hexosaminidase A (alpha polypeptide) isoform HEXA_1; hexosaminidase A (alpha polypeptide) isoform HEXA_2; hexosaminidase A (alpha polypeptide) isoform HEXA_3; hexosaminidase A (alpha polypeptide) isoform HEXA_4; hexosaminidase A (alpha polypeptide) isoform HEXA_5; Hexosaminidase subunit A; MGC99608; N-acetyl-alpha-glucosaminidase prepro-polypeptide; N-acetyl-beta-glucosaminidase subunit alpha; Unknown; unnamed protein product
Gene Aliases: HEXA; TSD
UniProt ID: (Human) P06865
Entrez Gene ID: (Human) 3073
skeletal system development
carbohydrate metabolic process
glycosaminoglycan biosynthetic process
N-glycan processing
lipid metabolic process
ganglioside catabolic process
lysosome organization
sensory perception of sound
locomotory behavior
adult walking behavior
lipid storage
sexual reproduction
glycosaminoglycan metabolic process
dermatan sulfate catabolic process
hyaluronan catabolic process
myelination
cell morphogenesis involved in neuron differentiation
neuromuscular process controlling posture
neuromuscular process controlling balance
carbohydrate derivative metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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