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Proteintech
HIP1 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-22231
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HIP1 fusion protein Ag17576
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: AELDELRRQR EDTEKAQRSL SEIERKAQAN EQRYSKLKEK YSELVQNHAD LLRKNAEVTK QVSMARQAQV DLEREKKELE DSLERISDQG QRKTQEQLEV LESLKQELAT SQRELQVLQG SLETSAQSEA NWAAEFAELE KERDSLVSGA AHREEELSAL RKELQDTQLK LASTEESMCQ LAKDQRKMLL VGSRKAAEQV IQDALNQLEE PPLISCAGSA DHLLSTVTSI SSCIEQLEKS WSQYLACPED ISGLLHSITL LAHLTSDAIA HGATTCLRAP PEPADSLTEA CKQYGRETLA YLASLEEEGS LENADSTAMR NCLSKIKAIG
Target Information
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIP I; HIP-1; HIP-I; hip1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I
Gene Aliases: 2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP-I; HIP1; ILWEQ; Kiaa4113; mKIAA4113; SHON; SHONbeta; SHONgamma
UniProt ID: (Human) O00291, (Mouse) Q8VD75
Entrez Gene ID: (Human) 3092, (Mouse) 215114
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cytoskeleton organization
cell differentiation
regulation of apoptotic process
positive regulation of receptor-mediated endocytosis
clathrin coat assembly
clathrin-mediated endocytosis
apoptotic signaling pathway
endocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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