|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:5000-1:20,000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 358 of Human HLA-E|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30600 targets HLA-E in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30600 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 358 of Human HLA-E.
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha chain E; E alpha chain; EA1.2; EA2.1; HLA class I histocompatibility antigen; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; HLA-6.2; lymphocyte antigen; MHC; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; QA1
Gene Aliases: EA1.2; EA2.1; HLA-6.2; HLA-E; HLAE; MHC; QA1
UniProt ID: (Human) P13747
Entrez Gene ID: (Human) 3133
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