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Invitrogen
HNF1A Polyclonal Antibody
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Product Details
PA5-35356
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 177-205 amino acids from the central region of human HNF1A
Conjugate
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: albumin proximal factor; hepatic nuclear factor 1; hepatocyte nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hnf-1 alpha; HNF-1-alpha; HNF-1A; interferon production regulator factor; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1; transcription factor 1, hepatic
Gene Aliases: AI323641; Hnf-1; HNF-1A; HNF1; HNF1-alpha; HNF1[a]; HNF1A; Hnf1alpha; IDDM20; LFB1; MODY3; TCF-1; TCF1
UniProt ID: (Human) P20823, (Mouse) P22361
Entrez Gene ID: (Human) 6927, (Mouse) 21405
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription regulatory region DNA binding
protein dimerization activity
RNA polymerase II core promoter sequence-specific DNA binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor binding
protein homodimerization activity
sequence-specific DNA binding
protein heterodimerization activity
DNA-binding transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of pronephros size
renal glucose absorption
glucose homeostasis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
glucose import
positive regulation of transcription initiation from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
blastocyst development
liver development
placenta development
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
fatty acid biosynthetic process
bile acid biosynthetic process
heme biosynthetic process
response to oxidative stress
protein localization
cholesterol metabolic process
response to glucose
bile acid and bile salt transport
fatty acid transport
insulin secretion
regulation of Wnt signaling pathway
embryonic limb morphogenesis
endocrine pancreas development
reverse cholesterol transport
bone resorption
regulation of hormone secretion
paraxial mesoderm formation
reproductive structure development
regulation of insulin secretion
SMAD protein signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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