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Invitrogen
HNF6 Polyclonal Antibody
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Product Details
PA5-23459
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 420-465 of human HNF6.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen is 88% homologous in Mouse and Opossum, and 82% homologous in Zebrafish.
Target Information
Hepatocyte nuclear factor 6 is a CUT homeobox family protein which is a transcription factor and contains a CUT DNA-binding domain and a homeobox DNA-binding domain. It is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. HNF6 is a ligand of the FOXM1 transcription factor network. HNF6, along with HNF4, controls gene expression in the liver. The expression levels of HNF6 and HNF4 rise steadily during development and that up- or down regulation of HNF6 and HNF4 expression generate premature or delayed expression of the g6pc gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-6; One cut domain family member 1; one cut domain, family member 1; One cut homeobox 1; transcription factor
Gene Aliases: HNF-6; HNF6; HNF6A; ONECUT1
UniProt ID: (Human) Q9UBC0
Entrez Gene ID: (Human) 3175, (Dog) 487558
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
sequence-specific double-stranded DNA binding
homeodomain transcription factor
liver development
regulation of cell-matrix adhesion
epithelial cell development
type B pancreatic cell differentiation
pancreatic A cell differentiation
pancreatic D cell differentiation
glucose metabolic process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
Notch signaling pathway
endoderm development
anatomical structure morphogenesis
cell migration
B cell differentiation
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
pancreas development
endocrine pancreas development
enteroendocrine cell differentiation
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
spleen development
cilium morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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