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Proteintech
HSPB8 Polyclonal Antibody
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Product Details
15287-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HSPB8 Fusion Protein Ag7456 (1-196 aa encoded by BC002673)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MADGQMPFS CHYPSRLRRD PFRDSPLSSR LLDDGFGMDP FPDDLTASWP DWALPRLSSA WPGTLRSGMV PRGPTATARF GVPAEGRTPP PFPGEPWKVC VNVHSFKPEE LMVKTKDGYV EVSGKHEEKQ QEGGIVSKNF TKKIQLPAEV DPVTVFASLS PEGLLIIEAP QVPPYSTFGE SSFNNELPQD SQEVTCT (1-196 aa encoded by BC002673)
Target Information
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-crystallin C chain; Alternatively spliced isoform of human HSPB8 protein; crystallin, alpha C; DHMN 2; E2-induced gene 1 protein; heat shock 22kDa protein 8; heat shock 27kDa protein 8; Heat shock protein; heat shock protein 8; Heat shock protein beta-8; Heat shock protein family B member 8; HMN 2; HSB8; HSP; HSPB 8; HSPB8; OTTHUMP00000239768; Protein kinase H11; Small stress protein-like protein HSP22; unnamed protein product
Gene Aliases: AU018630; AW413033; CMT2L; CRYAC; D5Ucla4; DHMN2; E2IG1; H11; H11K; HMN2; HMN2A; HMND2; HSP20-like; HSP22; HSPB8; HSPB8-N1; HSPB8-N2; MFM13; PP1629
UniProt ID: (Human) Q9UJY1, (Rat) Q9EPX0, (Mouse) Q9JK92
Entrez Gene ID: (Human) 26353, (Rat) 113906, (Mouse) 80888
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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