Haptoglobin is an a2-globulin plasma protein synthesized in the liver. It is an acute phase protein which also acts as a scavenger of hemoglobin from hemolyzed red cells. The haptoglobin monomer consists of two a and two beta chains; the a chains bay be hp1Fa, hp1Sa, or hp2a types while the beta chain is constant. Three major phenotypes are recognized: HP1-1, Hp2-1 and Hp-2-2, in which the hp1a chain bay be either the F or S type.
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Protein Aliases: binding peptide; Haptoglobin; Haptoglobin alpha chain; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; Haptoglobin beta chain; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; HP; Liver regeneration-related protein LRRG173; Zonulin
Gene Aliases: Ba1-647; BP; HP; HP-1; HP2ALPHA2; HPA1S; preHP2
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule