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Proteintech
ICAM3 Polyclonal Antibody
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Product Details
17699-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ICAM3 Fusion Protein Ag11955 (200-547 aa encoded by BC058903)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GLGLFVNTS APRQLRTFVL PVTPPRLVAP RFLEVETSWP VDCTLDGLFP ASEAQVYLAL GDQMLNATVM NHGDTLTATA TATARADQEG AREIVCNVTL GGERREAREN LTVFSFLGPI VNLSEPTAHE GSTVTVSCMA GARVQVTLDG VPAAAPGQPA QLQLNATESD DGRSFFCSAT LEVDGEFLHR NSSVQLRVLY GPKIDRATCP QHLKWKDKTR HVLQCQARGN PYPELRCLKE GSSREVPVGI PFFVNVTHNG TYQCQASSSR GKYTLVVVMD IEAGSSHFVP VFVAVLLTLG VVTIVLALMY VFREHQRSGS YHVREESTYL PLTSMQPTEA MGEEPSRAE (200-547 aa encoded by BC058903)
Target Information
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD50; CDw50; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
Gene Aliases: CD50; CDW50; ICAM-R; ICAM3
UniProt ID: (Human) P32942
Entrez Gene ID: (Human) 3385
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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