Immunogen sequence: MALETICRPS GRKSSKMQAF RIWDVNQKTF YLRNNQLVAG YLQGPNVNLE EKIDVVPIEP HALFLGIHGG KMCLSCVKSG DETRLQLEAV NITDLSENRK QDKRFAFIRS DSGPTTSFES AACPGWFLCT AMEADQPVSL TNMPDEGVMV TKFYFQEDE; Positive Samples: Mouse pancreas; Cellular Location: Cytoplasm
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
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Protein Aliases: CD121A; D2S1473; IL 1 receptor antagonist; il-1 receptor; il-1r; IL-1RN; IL1 inhibitor; il1 receptor; IL1 receptor antagonist; IL1-RA; IL1R; IL1RN (IL1F3); interleukin-1 receptor; Interleukin-1 receptor antagonist protein; IRAP; MGC10430; P80
Gene Aliases: F630041P17Rik; IL-1ra; Il1rn