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FIGURE: 1 / 3
INHA Antibody (PA5-141076) in ICC/IF
Immunocytochemistry analysis of Inhibin alpha in PANC-1 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Samples were incubated in Inhibin alpha Polyclonal antibody (Product # PA5-141076) using a dilution of 1:50 for 1 hour at room temperature, washed with PBS followed by Alexa Fluor®488 Goat anti-Rabbit IgG secondary antibody at a dilution of 1:1,000. The nuclear counter stain is DAPI (blue).
Product Details
PA5-141076
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human Inhibin alpha aa 240-290.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2932528
Target Information
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A inhibin subunit; A-inhibin subunit; IHA; inhibin; Inhibin alpha chain
Gene Aliases: AW555078; INHA
UniProt ID: (Human) P05111, (Rat) P17490, (Mouse) Q04997
Entrez Gene ID: (Human) 3623, (Rat) 24504, (Mouse) 16322
skeletal system development
ovarian follicle development
cell cycle arrest
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
nervous system development
male gonad development
response to external stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
erythrocyte differentiation
regulation of cell proliferation
negative regulation of phosphorylation
hemoglobin biosynthetic process
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of interferon-gamma biosynthetic process
negative regulation of B cell differentiation
negative regulation of macrophage differentiation
negative regulation of cell cycle
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
cell development
regulation of cell cycle
SMAD protein signal transduction
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