Search
Proteintech
INSIG2 Polyclonal Antibody, CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
CL488-24766
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
INSIG2 fusion protein Ag14072
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: TASAVIGLL YPCIDRHLGE PHKFKREWSS VMRCVAVFVG INHASAKVDF DNNIQLSLTL AA
Target Information
INSIG2 is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: INSIG-2; INSIG-2 membrane protein; INSIG2 membrane protein; insulin induced protein 2; Insulin-induced gene 2 protein; MGC26273; unnamed protein product
Gene Aliases: 2900053I11Rik; C730043J18Rik; INSIG-2; INSIG2
UniProt ID: (Human) Q9Y5U4, (Rat) Q80UA9, (Mouse) Q91WG1
Entrez Gene ID: (Human) 51141, (Rat) 288985, (Mouse) 72999
triglyceride metabolic process
cholesterol biosynthetic process
response to sterol depletion
cholesterol metabolic process
negative regulation of steroid biosynthetic process
sterol biosynthetic process
response to insulin
SREBP signaling pathway
response to lipid
inner ear morphogenesis
middle ear morphogenesis
negative regulation of fatty acid biosynthetic process
palate development
cranial suture morphogenesis
response to fatty acid
NLS-bearing protein import into nucleus
lipid metabolic process
steroid metabolic process
cellular response to insulin stimulus
SREBP-SCAP complex retention in endoplasmic reticulum
positive regulation of cholesterol biosynthetic process
protein maturation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support