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          • Primary Antibodies ›
          • Integrin beta 1 (CD29) Antibodies

          Proteintech

          Integrin beta-1 Polyclonal Antibody

          62 References
          View all (100) Integrin beta 1 (CD29) antibodies

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          Cite Integrin beta-1 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (9)
          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 9

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          Integrin beta-1 Antibody (12594-1-AP) in IHC (P)

          Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using (Product # 12594-1-AP) (Integrin Beta 1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Integrin beta-1 Antibody in Western Blot (WB)
          Integrin beta-1 Antibody in Western Blot (WB)
          Integrin beta-1 Antibody in Western Blot (WB)
          Integrin beta-1 Polyclonal Antibody

          Product Details

          12594-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:8,000
          View 31 publications 31 publications

          Immunohistochemistry (IHC)

          -
          View 9 publications 9 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:1,000-1:4,000
          -

          Immunocytochemistry (ICC/IF)

          -
          View 15 publications 15 publications

          Immunoprecipitation (IP)

          -
          View 1 publication 1 publication

          Miscellaneous PubMed (Misc)

          -
          View 3 publications 3 publications

          Not applicable (N/A)

          -
          View 3 publications 3 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Deer, Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Integrin beta-1 Fusion Protein Ag3078 (30-359 aa encoded by BC020057)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.65 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: ANAKSCGEC IQAGPNCGWC TNSTFLQEGM PTSARCDDLE ALKKKGCPPD DIENPRGSKD IKKNKNVTNR SKGTAEKLKP EDITQIQPQQ LVLRLRSGEP QTFTLKFKRA EDYPIDLYYL MDLSYSMKDD LENVKSLGTD LMNEMRRITS DFRIGFGSFV EKTVMPYIST TPAKLRNPCT SEQNCTSPFS YKNVLSLTNK GEVFNELVGK QRISGNLDSP EGGFDAIMQV AVCGSLIGWR NVTRLLVFST DAGFHFAGDG KLGGIVLPND GQCHLENNMY TMSHYYDYPS IAHLVQKLSE NNIQTIFAVT EEFQPVYKEL KNLIPKSAVG T (30-359 aa encoded by BC020057)

          Target Information

          CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly during leukocyte emigration and extravascular migration. It is involved in regulating tissue damage and disease symptoms related to inflammatory bowel disease. In the presence of anti-tumor drugs, decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. ITGB1-dependent mechanisms enhance cytokine secretion in human airway smooth muscle in response to IL-1beta, facilitated by fibronectin and type I collagen. More than eight beta subunits with numerous splice variant isoforms have been identified in mammals, including two major forms: beta1A and beta1D. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Beta OL; Beta oligodendroglia; CD29; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; integrin beta 1; integrin beta 1 (fibronectin receptor beta); Integrin beta-1; integrin beta-1 subunit (cytoplasmic domain); Integrin beta1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; unnamed protein product; very late activation protein, beta polypeptide; VLA-4 subunit beta

          View more View less

          Gene Aliases: 4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; FNRB; Gm9863; GPIIA; ITGB1; MDF2; MSK12; VLA-BETA; VLAB

          View more View less

          UniProt ID: (Human) P05556, (Mouse) P09055, (Rat) P49134

          View more View less

          Entrez Gene ID: (Human) 3688, (Mouse) 16412, (Rat) 24511

          View more View less

          Function(s)
          magnesium ion binding virus receptor activity fibronectin binding protease binding actin binding integrin binding calcium ion binding protein binding coreceptor activity protein kinase binding C-X3-C chemokine binding signaling receptor activity laminin binding macromolecular complex binding cadherin binding metal ion binding protein heterodimerization activity cell adhesion molecule binding collagen binding involved in cell-matrix adhesion integrin binding involved in cell-matrix adhesion protein tyrosine kinase binding glycoprotein binding receptor activity receptor binding collagen binding kinase binding protein domain specific binding protein complex binding peptide binding alpha-actinin binding integrin
          Process(es)
          G1/S transition of mitotic cell cycle establishment of mitotic spindle orientation angiogenesis in utero embryonic development cell migration involved in sprouting angiogenesis positive regulation of neuroblast proliferation phagocytosis cellular defense response cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion calcium-independent cell-matrix adhesion transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway neuroblast proliferation muscle organ development myoblast fusion cell proliferation germ cell migration visual learning regulation of collagen catabolic process positive regulation of fibroblast migration response to muscle activity cell migration formation of radial glial scaffolds central nervous system neuron differentiation CD40 signaling pathway cell projection organization lamellipodium assembly B cell differentiation extracellular matrix organization positive regulation of cell migration neuron projection development cell-substrate adhesion receptor internalization cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion negative regulation of Rho protein signal transduction wound healing, spreading of epidermal cells maintenance of blood-brain barrier positive regulation of apoptotic process stress fiber assembly positive regulation of GTPase activity sarcomere organization myoblast differentiation negative regulation of neuron differentiation positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis negative regulation of vasoconstriction viral entry into host cell mesodermal cell differentiation myoblast fate specification axon extension dendrite morphogenesis regulation of developmental process modulation of synaptic transmission leukocyte tethering or rolling regulation of cell cycle positive regulation of protein kinase B signaling positive regulation of glutamate uptake involved in transmission of nerve impulse cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation cardiac cell fate specification regulation of biological quality cellular response to low-density lipoprotein particle stimulus basement membrane organization positive regulation of wound healing cell-cell adhesion regulation of spontaneous synaptic transmission reactive gliosis positive regulation of vascular endothelial growth factor signaling pathway positive regulation of protein localization to plasma membrane regulation of synapse pruning negative regulation of anoikis cell fate specification tissue homeostasis cellular calcium ion homeostasis regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of cell-substrate adhesion positive regulation of neuron projection development negative regulation of cell projection organization protein transport within lipid bilayer positive regulation of MAPK cascade negative regulation of cell differentiation positive regulation of neuron differentiation positive regulation of endocytosis cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation bicellular tight junction assembly positive regulation of establishment of protein localization to plasma membrane response to activity response to nutrient levels response to gonadotropin response to drug maternal process involved in female pregnancy cellular response to mechanical stimulus cellular response to vitamin D cellular response to ionizing radiation response to transforming growth factor beta
          It has to be done as per old AB suggested Products section.

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