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Immunogen sequence: EDNMKLLPVD CERKTDEFCQ AKQKAALLEL LHELYNFLAI QAGNFECGNP ENLKSKCIPV MEAQEYIANV TSSSSAKFEA ALTWILSSNK DVGIWLKGED QSELVTTVDK VVCLESAHP
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.
The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hLEM2; LEM domain-containing protein 2
Gene Aliases: CTRCT42; dJ482C21.1; LEMD2; NET25
UniProt ID: (Human) Q8NC56
Entrez Gene ID: (Human) 221496
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