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Product Details
PA5-120697
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500 - 1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50 - 1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human LLGL1 (NP_004131.3). |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.89 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.01% thimerosal |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2914269 |
Product Specific Information
Positive test controls include: OVCAR3, A-431, U-251MG, Mouse testis, Mouse brain, Rat testis.
Target Information
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DLG4; Hugl protein; Hugl-1; Human homolog to the D-lgl gene protein; lethal giant larvae homolog 1; lethal giant larvae homolog 1, scribble cell polarity complex component; Lethal(2) giant larvae protein homolog 1; LLGL; Mgl-1; Mlgl
Gene Aliases: AI325176; DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL; LLGL1; Llglh; Mgl1; Rgl-1; Rgl1
UniProt ID: (Human) Q15334, (Mouse) Q80Y17
Entrez Gene ID: (Human) 3996, (Rat) 54265, (Mouse) 16897
Molecular Function:
membrane trafficking regulatory protein
protein complex assembly
exocytosis
Golgi to plasma membrane transport
axonogenesis
regulation of Notch signaling pathway
regulation of exocytosis
neurogenesis
cortical actin cytoskeleton organization
regulation of establishment or maintenance of cell polarity
positive regulation of GTPase activity
regulation of protein secretion
establishment of spindle orientation
maintenance of apical/basal cell polarity
brain development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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