Invitrogen

LRRTM2 Polyclonal Antibody

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LRRTM2 Antibody in Immunohistochemistry (IHC) — Immunohistochemistry of LRRTM2 in human brain tissue with LRRTM2 Polyclonal Antibody (Product # PA5-21097) at 2.5 µg/mL.

LRRTM2 Antibody in Western Blot (WB) — Western Blot analysis of LRRTM2 in SK-N-SH cell lysate with LRRTM2 Polyclonal Antibody (Product # PA5-21097) at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.

Product Details

PA5-21097

Applications	Tested Dilution	Publications
Western Blot (WB)	1 µg/mL	View 1 publication 1 publication
Immunohistochemistry (IHC)	2.5 µg/mL	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A 17 amino acid peptide near the carboxy terminus of human LRRTM2. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS
Contains	0.02% sodium azide
Storage conditions	Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
RRID	AB_11153649

Product Specific Information

A suggested positive control is SK-N-SH cell lysate.

PA5-21097 can be used with blocking peptide PEP-1211.

Target Information

The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density.

eLife

Walkup WG,Mastro TL,Schenker LT,Vielmetter J,Hu R,Iancu A,Reghunathan M,Bannon BD,Kennedy MB

PA5-21097 was used in western blot demonstrate that synGAP-alpha1 regulates postsynaptic density composition by restricting binding to the PDZ domains of PSD-95

Tue Sep 13 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Leucine-rich repeat neuronal 2 protein; leucine-rich repeat transmembrane neuronal 2 protein; Leucine-rich repeat transmembrane neuronal protein 2

Gene Aliases: AI851755; BB129880; C630011A14Rik; KIAA0416; LRRN2; LRRTM2; mKIAA0416

UniProt ID: (Human) O43300, (Mouse) Q8BGA3, (Rat) D4A7P2

Entrez Gene ID: (Human) 26045, (Mouse) 107065, (Rat) 685472

Molecular Function: transmembrane signal receptor