Search
Invitrogen
RT1.D Monoclonal Antibody (OX-17)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-70009
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OX-17
Immunogen
Rat spleen membrane glycoproteins depleted of Ia-A antigens
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
250 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
Target Information
RT1.D is a gene located within the major histocompatibility complex (MHC) region of the rat genome, specifically part of the RT1 complex. RT1.D, along with its counterpart RT1.B, comprises class II MHC genes, which are key players in the adaptive immune response. These genes encode for proteins that present extracellularly derived peptides to helper T cells (CD4+ T cells), facilitating the activation and regulation of immune responses. The RT1.D gene product is analogous to human HLA-DR and mouse I-A/I-E molecules, playing an essential role in antigen presentation and immune recognition. RT1.D genes are highly polymorphic, which influences susceptibility to various diseases and are often utilized in studies involving autoimmune diseases, immune response, and transplantation immunology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: MHC class II RT1D beta1 chain antigen; rat class I D; RT1 class II; RT1 class II histocompatibility antigen, D-1 beta chain; RT1-D beta; unnamed protein product
Gene Aliases: Db1; RT1-Db; RT1-Db1n
Entrez Gene ID: (Rat) 294270
positive regulation of T cell mediated cytotoxicity
inflammatory response to antigenic stimulus
myeloid dendritic cell antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class II
peptide antigen assembly with MHC class II protein complex
positive regulation of T cell mediated immune response to tumor cell
negative regulation of inflammatory response to antigenic stimulus
immune response
humoral immune response
signal transduction
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
macrophage differentiation
regulation of interleukin-10 production
regulation of interleukin-4 production
negative regulation of interferon-gamma production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T-helper 1 type immune response
negative regulation of T cell proliferation
positive regulation of memory T cell differentiation
regulation of T-helper cell differentiation
positive regulation of monocyte differentiation
positive regulation of immune response
T cell receptor signaling pathway
positive regulation of T cell activation
protein tetramerization
response to dexamethasone
positive regulation of CD4-positive, alpha-beta T cell activation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support