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Invitrogen
Laminin beta-2/gamma-1 Monoclonal Antibody (A5), Biotin
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Product Details
MA5-14646
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse,
Rat,
Rhesus monkey
Host/Isotype
Rat
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
A5
Immunogen
Murine EHS laminin preparation
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-14646 targets Laminin B2/gamma1 in IF, IHC (F), IHC (P, F), and IP applications and shows reactivity with Human and mouse samples.
The MA5-14646 immunogen is mouse EHS laminin preparation.
Target Information
Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains. They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AA408497; Lama; Laminin B1s chain; Laminin B2 chain; laminin B2 precursor; Laminin S; Laminin subunit beta-2; Laminin subunit gamma-1; laminin, beta 2 (laminin S); laminin, gamma 1 (formerly LAMB2); Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit beta; Laminin-11 subunit gamma; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-2 subunit gamma; Laminin-3 subunit beta; Laminin-3 subunit gamma; Laminin-4 subunit beta; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit beta; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit beta; Laminin-9 subunit gamma; S-LAM beta; S-LAM gamma; S-laminin subunit beta; S-laminin subunit gamma; unnamed protein product
Gene Aliases: AW211941; Lamb-2; LAMB2; LAMC1; LAMS; NPHS5; npht; PIERS
UniProt ID: (Human) P55268, (Human) P11047, (Mouse) Q61292
Entrez Gene ID: (Human) 3913, (Human) 3915, (Mouse) 16779, (Mouse) 226519
integrin binding
structural molecule activity
extracellular matrix structural constituent
protein binding
structural constituent of synapse-associated extracellular matrix
extracellular matrix constituent conferring elasticity
glycosphingolipid binding
extracellular matrix protein
DNA metabolism protein
cell morphogenesis
cell adhesion
axon guidance
neuromuscular junction development
visual perception
astrocyte development
Schwann cell development
neuron projection development
positive regulation of cell adhesion
axon extension involved in regeneration
synapse organization
positive regulation of muscle cell differentiation
retina development in camera-type eye
metanephric glomerular visceral epithelial cell development
metanephric glomerular basement membrane development
regulation of basement membrane organization
positive regulation of integrin-mediated signaling pathway
endoderm development
tissue development
cell migration
extracellular matrix disassembly
hemidesmosome assembly
substrate adhesion-dependent cell spreading
maintenance of blood-brain barrier
positive regulation of epithelial cell proliferation
protein-containing complex assembly
cell morphogenesis involved in differentiation
protein complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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