JAK2 Monoclonal Antibody (1C1)

nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding kinase activity transferase activity protein kinase binding heme binding receptor activator activity type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding identical protein binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding

microglial cell activation positive regulation of cytokine production adaptive immune response immune system process chromatin organization chromatin remodeling transcription from RNA polymerase II promoter apoptotic process immune response response to oxidative stress cell adhesion signal transduction enzyme linked receptor protein signaling pathway positive regulation of cytosolic calcium ion concentration JAK-STAT cascade mesoderm development positive regulation of cell proliferation negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress hormone-mediated signaling pathway positive regulation of platelet activation negative regulation of cardiac muscle cell apoptotic process positive regulation of cell-substrate adhesion cytokine-mediated signaling pathway regulation of cell-cell adhesion negative regulation of cell-cell adhesion actin filament polymerization myeloid cell differentiation cell differentiation erythrocyte differentiation positive regulation of cell migration axon regeneration lipopolysaccharide-mediated signaling pathway mineralocorticoid receptor signaling pathway positive regulation of insulin secretion positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation response to hydroperoxide tumor necrosis factor-mediated signaling pathway host programmed cell death induced by symbiont response to tumor necrosis factor post-embryonic hemopoiesis intracellular signal transduction interleukin-12-mediated signaling pathway cellular response to interleukin-3 interleukin-5-mediated signaling pathway collagen-activated signaling pathway interleukin-23-mediated signaling pathway interleukin-3-mediated signaling pathway granulocyte-macrophage colony-stimulating factor signaling pathway erythropoietin-mediated signaling pathway thrombopoietin-mediated signaling pathway positive regulation of T cell proliferation positive regulation of protein import into nucleus positive regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process post-translational protein modification T-helper 1 cell differentiation innate immune response positive regulation of MHC class II biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter regulation of JAK-STAT cascade positive regulation of JAK-STAT cascade regulation of alpha-beta T cell activation response to antibiotic protein autophosphorylation platelet-derived growth factor receptor signaling pathway regulation of inflammatory response modulation of synaptic transmission positive regulation of cell activation positive regulation of NK T cell proliferation positive regulation of protein kinase B signaling interferon-gamma-mediated signaling pathway positive regulation of SMAD protein import into nucleus growth hormone receptor signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway positive regulation of growth hormone receptor signaling pathway negative regulation of growth hormone receptor signaling pathway mammary gland epithelium development interleukin-6-mediated signaling pathway positive regulation of leukocyte proliferation response to interleukin-12 interleukin-35-mediated signaling pathway cellular response to lipopolysaccharide cellular response to dexamethasone stimulus extrinsic apoptotic signaling pathway cellular response to virus positive regulation of cold-induced thermogenesis defense response to symbiont negative regulation of cytokine production involved in inflammatory response positive regulation of platelet aggregation positive regulation of intracellular signal transduction positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of epithelial cell apoptotic process positive regulation of vascular smooth muscle cell proliferation regulation of postsynapse to nucleus signaling pathway negative regulation of 3'-UTR-mediated mRNA stabilization positive regulation of T-helper 17 type immune response positive regulation of apoptotic signaling pathway