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Invitrogen

Prohibitin Monoclonal Antibody (5H7)

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View all (53) Prohibitin antibodies

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Product Details

MA5-15899

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5H7

Immunogen

Purified recombinant fragment of human PHB expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152872

Product Specific Information

MA5-15899 targets PHB in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.

The MA5-15899 immunogen is purified recombinant fragment of human PHB expressed in E. Coli. .

MA5-15899 detects PHB which has a predicted molecular weight of approximately 30kDa.

Target Information

Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-cell receptor-associated protein 32; BAP 32; epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; gastric cancer susceptibility protein; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; PHB; prohibitin; Prohibitin 1; unnamed protein product

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Gene Aliases: BAP32; HEL-215; HEL-S-54e; PHB; PHB1

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UniProt ID: (Human) P35232, (Mouse) P67778, (Rat) P67779

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Entrez Gene ID: (Human) 5245, (Mouse) 18673, (Rat) 25344

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Function(s)
complement component C3a binding complement component C3b binding transcription corepressor activity protein binding enzyme binding proteinase activated receptor binding histone deacetylase binding protein heterodimerization activity RNA polymerase II transcription factor activity, sequence-specific DNA binding protein C-terminus binding transcription regulatory region DNA binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter mitochondrion organization negative regulation of cell proliferation negative regulation of transcription by competitive promoter binding histone deacetylation negative regulation of cell growth negative regulation of protein catabolic process negative regulation of apoptotic process positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of complement activation protein stabilization progesterone receptor signaling pathway negative regulation of androgen receptor signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to interleukin-6 DNA biosynthetic process negative regulation of glucocorticoid receptor signaling pathway ovarian follicle development ovarian follicle atresia organ regeneration response to cytokine response to immobilization stress response to drug response to peptide hormone response to ethanol positive regulation of immunoglobulin production signal transduction positive regulation of gene expression positive regulation of interleukin-17 production RIG-I signaling pathway regulation of gene expression, epigenetic B cell activation regulation of apoptotic process positive regulation of neuron apoptotic process modulation by host of viral RNA genome replication viral entry into host cell positive regulation of smooth muscle cell proliferation positive regulation of protein kinase B signaling T-helper 17 type immune response antiviral innate immune response positive regulation of NIK/NF-kappaB signaling
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